Sam '23 places 1st in regional science fair
Through his research, Sam Lustig '23 concluded that protein knockdown technology is the preferred method of treatment for some prostate cancer patients.
Sam Lustig '23 won the Cellular/Molecular Biology category of the Middle Tennessee Science and Engineering Fair at Belmont University on Friday, March 25.
He writes, “In my project, we introduced a compound called A1874 to prostate cancer cells. The compound is a proteolysis targeting chimera (PROTAC) which degrades the intracellular protein, BRD4. BRD4 is amplified in numerous prostate cancer phenotypes – the protein plays a role in chemotherapeutic resistance and facilitation of tumor proliferation. There is a current standard-of-care BRD4 inhibitor, but the problem with this inhibitor is that it has lower specificity for the protein and inflicts cell death at higher concentrations in a reversible process, whereas, A1874 targets BRD4 in an irreversible process. We showed that A1874 inhibits prostate cancer cell proliferation at low concentrations in BRD4 over-expressive prostate cancer cell lines. Thus, targeting BRD4 via protein knockdown technology provides promise over classic inhibition as a possible targeted therapy for prostate cancer patients with heightened BRD4 expression."
More USN News
List of 3 news stories.
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MS Quiz Bowl team heads to national championships
The Quiz Bowl team traveled to Bowling Green, Kentucky, to face several top teams from across the country at this year's South Warren Tournament. USN's second-place finish earned the team an invitation to the National Academic Quiz Tournaments' National Championships in May.Read More -
Alumni return to share insights with students
Read MoreIn an inspiring new initiative, USN's health care career spotlight, organized by Ruchika Ramachandran ’27 and Yvonne Wang ’27, brought a wealth of alumni back to the school for an evening of shared expertise and personal stories. This first-of-its-kind event was a great example of the power of connection, mentorship, and community evident throughout the USN community. -
Band students meet composer Larry Clark
Ahead of the All Bands Winter Concert, students got to play for Larry Clark, the composer who arranged the holiday medley that the band will perform at 7 p.m. Tuesday, December 9 in Durnan Auditorium.Read More
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Email: info@usn.org
River Campus
1200 County Hospital Road
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2000 Edgehill Ave.
Nashville, TN 37212
Phone: 615-321-8000
Fax: 615-321-0889
Email: info@usn.org
River Campus
1200 County Hospital Road
Nashville, TN 37218
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University School of Nashville models the best educational practices. In an environment that represents the cultural and ethnic composition of Metropolitan Nashville, USN fosters each student’s intellectual, artistic, and athletic potential, valuing and inspiring integrity, creative expression, a love of learning, and the pursuit of excellence.
University School of Nashville models the best educational practices. In an environment that represents the cultural and ethnic composition of Metropolitan Nashville, USN fosters each student’s intellectual, artistic, and athletic potential, valuing and inspiring integrity, creative expression, a love of learning, and the pursuit of excellence.