Sam '23 places 1st in regional science fair
Through his research, Sam Lustig '23 concluded that protein knockdown technology is the preferred method of treatment for some prostate cancer patients.
Sam Lustig '23 won the Cellular/Molecular Biology category of the Middle Tennessee Science and Engineering Fair at Belmont University on Friday, March 25.
He writes, “In my project, we introduced a compound called A1874 to prostate cancer cells. The compound is a proteolysis targeting chimera (PROTAC) which degrades the intracellular protein, BRD4. BRD4 is amplified in numerous prostate cancer phenotypes – the protein plays a role in chemotherapeutic resistance and facilitation of tumor proliferation. There is a current standard-of-care BRD4 inhibitor, but the problem with this inhibitor is that it has lower specificity for the protein and inflicts cell death at higher concentrations in a reversible process, whereas, A1874 targets BRD4 in an irreversible process. We showed that A1874 inhibits prostate cancer cell proliferation at low concentrations in BRD4 over-expressive prostate cancer cell lines. Thus, targeting BRD4 via protein knockdown technology provides promise over classic inhibition as a possible targeted therapy for prostate cancer patients with heightened BRD4 expression."
More USN News
List of 3 news stories.
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USN graduates 98 plus 1 during Commencement
Seniors turned their tassels and graduated from University School of Nashville on Sunday, May 17, on the Back Lawn. Visit usn.org/classof2026 for more highlights from their last year on Edgehill and to learn what they will do next.Read More -
Spring sports season ends with podium finishes, trophies
The girls lacrosse team ended its season in overtime to become state runner-up. Tennis players Carter Kojetin '29 finished as a state quarterfinalist, Sophie Oliver '26 and Mary Kate Adler '28 finished as state semifinalists, and Veer Kodali '29 and Max Parker '29 finished as state champions. Meanwhile, eight runners competed at the state track and field meet in Knoxville, where Griffin Davidson '27, Caleb Freifeld '28, Drew Zwerner '28, and Jack Fruin '27, sprinted to first in the 4x800m relay and Jack also placed first in the 800m dash.Read More -
USN creates the Juliet Douglas Endowed Fund for Student Success
For the entire USN community: an invitation to give in gratitude, in celebration, and in honor of the woman who has given so much to our school. Make a gift at usn.org/giving to support students with needs beyond tuition and honor Interim Director Juliet Douglas.Read More
Contact
Edgehill Campus
2000 Edgehill Ave.
Nashville, TN 37212
Phone: 615-321-8000
Fax: 615-321-0889
Email: info@usn.org
River Campus
1200 County Hospital Road
Nashville, TN 37218
2000 Edgehill Ave.
Nashville, TN 37212
Phone: 615-321-8000
Fax: 615-321-0889
Email: info@usn.org
River Campus
1200 County Hospital Road
Nashville, TN 37218
USN Mission:
University School of Nashville models the best educational practices. In an environment that represents the cultural and ethnic composition of Metropolitan Nashville, USN fosters each student’s intellectual, artistic, and athletic potential, valuing and inspiring integrity, creative expression, a love of learning, and the pursuit of excellence.
University School of Nashville models the best educational practices. In an environment that represents the cultural and ethnic composition of Metropolitan Nashville, USN fosters each student’s intellectual, artistic, and athletic potential, valuing and inspiring integrity, creative expression, a love of learning, and the pursuit of excellence.